Protein-losing enteropathy and mixed connective-tissue disease

A case of a person with a mixed connective-tissue disease, who subsequently developed protein-losing enteropathy with a partial response to prednisolone therapy, is presented. Protein-losing enteropathy has been reported in several patients with systemic lupus erythematosus but not in patients with mixed connective-tissue disease. This case broadens the association of protein-losing enteropathy with autoimmune diseases and suggests that the diagnosis should be considered in patients with mixed connective-tissue disease who have hypoalbuminaemia.