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Arrhythmias in Children with Peripherally Inserted Central Catheters (PICCs)
Santokh S Dhillon1, Bairbre Connolly2, Omid Shearkhani2
1Division of Cardiology, Department of Pediatrics, IWK Health Centre/Dalhousie University, Halifax, NS, B3K 6R8, Canada. santokh.dhillon@iwk.nshealth.ca.
Insights
Cardiac arrhythmias are uncommon in children with peripherally inserted central catheters (PICCs), occurring in 1% of cases. Deeper PICC tip placement in the superior vena cava or right atrium increases arrhythmia risk.
Area of Science:
- Pediatric Cardiology
- Vascular Access Devices
- Cardiac Electrophysiology
Background:
- Peripherally inserted central catheters (PICCs) are widely used in pediatric patients.
- Cardiac arrhythmias are a potential complication of central venous catheterization.
- Understanding risk factors for PICC-associated arrhythmias in children is crucial for patient safety.
Purpose of the Study:
- To determine the prevalence, types, and risk factors of cardiac arrhythmias in children with PICCs.
- To investigate the association between PICC tip position and the occurrence of arrhythmias.
- To evaluate the management and outcomes of these arrhythmias.
Main Methods:
- A retrospective, case-control study of 3180 pediatric patients (<18 years) with PICCs from 2009-2013.
- New-onset arrhythmias were identified and confirmed via ECGs and physician records.
- PICC tip position was measured in rib units (RU) and vertebra units (VU) from chest X-rays; cases were matched 1:1 to controls.
Main Results:
- Thirty-one children (1%) developed arrhythmias, predominantly atrial (71%).
- Arrhythmias were more frequent when the PICC tip was positioned deeper than 6.25 RU (Odds Ratio 4.5).
- Underlying structural heart disease was present in 45% of cases versus 29% of controls.
Conclusions:
- The prevalence of PICC-associated arrhythmias in children is low.
- Deeper PICC tip placement is a significant risk factor for developing arrhythmias.
- Arrhythmias were manageable with medical therapy or PICC repositioning.
Abstract:
To analyze the prevalence, types, and risk factors for cardiac arrhythmias associated with peripherally inserted central catheters (PICCs) in children. This is a case-control single center retrospective study. From 3180 PICCs inserted in children (< 18 years old) between 2009 and 2013, cases with new onset arrhythmias were identified. Demographics, type and timing of arrhythmias, and possible risk factors were analyzed. ECGs, rhythm strips, physicians' records, and anti-arrhythmic management were confirmatory. The level of the PICC's tip in the superior vena cava (SVC) or right atrium (RA) was ascertained from chest X-rays and counted in rib units (RU) and vertebra units (VU). Cases were matched (1:1 ratio) to controls by weight and date of insertion. Descriptive statistics were performed. A two-sided p value < 0.05 was considered significant. Thirty-one children (1%) developed arrhythmias, 16/31 (56%) were males, and 24/31 (77%) were < 1-year age. Arrhythmias were atrial 22 (71%), ventricular 4 (13%), and undetermined 5 (16%). Median PICC dwell time was 16 days. 14/31 (45%) cases and 9/31 (29%) controls had underlying structural heart disease. PICCs central tip position was lower among cases than controls (RU 6 vs 5). Odds Ratio for developing arrhythmia was 4.5 (95% CI 0.98-20.83) if the tip lays below 6.25RU. Arrhythmias were resolved with anti-arrhythmic agents in 52% (16/31) and with PICC exchange/manipulation in 32% (10/31) cases. Two children died unrelated to arrhythmia. Prevalence of arrhythmias associated with PICCs in children is low (1%). Arrhythmias are 4.5 times more likely when PICC's central tip position is deeper than 6.25RU.
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