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Tumor Budding Detection System in Whole Slide Pathology Images.

Mohammad F A Fauzi1, Wei Chen2, Debbie Knight2

  • 1Faculty of Engineering, Multimedia University, 63100, Cyberjaya, SGR, Malaysia. faizal1@mmu.edu.my.

Journal of Medical Systems
|December 20, 2019
PubMed
Summary
This summary is machine-generated.

Tumor budding (TB), an indicator of poor prognosis in colorectal cancer, can now be automatically detected. A new computer algorithm analyzes whole-slide images to quantify TB, aiding pathologists in daily practice.

Keywords:
Colorectal cancerDigital pathologyTumor buddingTumor classification

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Area of Science:

  • Oncology
  • Pathology
  • Computer Science

Background:

  • Tumor budding (TB) is an adverse prognostic factor in various cancers, including colorectal carcinoma (CRC).
  • In CRC, TB is linked to lymph node metastasis and poorer patient outcomes.
  • Current manual assessment of TB by light microscopy is time-consuming and requires expert evaluation.

Purpose of the Study:

  • To develop a computer-assisted image analysis system for automated detection and morphometric analysis of tumor budding in CRC.
  • To assist pathologists in the daily practice of tumor budding assessment.

Main Methods:

  • Development of a de novo computer algorithm for TB detection.
  • Application of the algorithm to whole-slide Cytokeratin AE1/3 images of CRC.
  • Automation of morphometric analysis for tumor budding quantification.

Main Results:

  • Successful development of a system for automated tumor budding detection in CRC.
  • The system automates the time-consuming tasks of locating, counting, and scoring TB.
  • Potential to improve efficiency and consistency in pathology reporting of TB.

Conclusions:

  • Computer-assisted image analysis offers a valuable tool for automating tumor budding assessment in CRC.
  • Automated TB detection can support pathologists in providing timely and accurate prognostic information.
  • This technology can enhance the clinical utility of tumor budding as a prognostic marker.