Nonlinear mechanics of soft composites: hyperelastic characterization of white matter tissue components

This paper presents a bi-directional closed-form analytical solution, in the framework of nonlinear soft composites mechanics, for top-down hyperelastic characterization of brain white matter tissue components, based on the directional homogenized responses of the tissue in the axial and transverse directions. The white matter is considered as a transversely isotropic neo-Hookean composite made of unidirectional distribution of axonal fibers within the extracellular matrix. First, two homogenization formulations are derived for the homogenized axial and transverse shear moduli of the tissue, based on definition of the strain energy density function. Next, the rule of mixtures and Hashin-Shtrikman theories are used to derive two coupled nonlinear equations which correlates the tissue shear moduli to these of its components. Closed-form solutions for shear moduli of the components are then obtained by solving these equations simultaneously. In order to validate the hyperelastic characteristics of components obtained in previous step, they are used in a bottom-up approach in a micromechanical model of the tissue with the aim of predicting the directional homogenized responses of the tissue. Comparison of model predictions with the experimental test results reported for corona radiata and corpus callosum white matter structures reveals very good agreements with the experimental results in both directions. The model predictions are also in good agreement with the analytical solution obtained by the iterated homogenization technique. Results indicate that axonal fibers are almost ten times stiffer than the extracellular matrix under large deformations.