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Related Concept Videos

Psychosurgery01:30

Psychosurgery

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Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
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Management of persistent and recurrent Cushing's disease: Efficacy of repeat transsphenoidal surgery.

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Related Experiment Video

Updated: Jan 1, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Surgery for prolactinomas: a better choice?

Jürgen Honegger1, Isabella Nasi-Kordhishti2, Nuran Aboutaha2

  • 1Department of Neurosurgery, University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany. juergen.honegger@med.uni-tuebingen.de.

Pituitary
|December 20, 2019
PubMed
Summary
This summary is machine-generated.

Transsphenoidal surgery (TSS) offers high success rates for prolactinomas, presenting a favorable alternative to long-term dopamine-agonist (DA) treatment. Surgery is increasingly indicated due to DA risks and patient preference for a potential cure.

Keywords:
Dopamine-agonistsEndocrinological outcomeHyperprolactinemiaHypopituitarismProlactinomaTranssphenoidal surgery

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Area of Science:

  • Neurosurgery
  • Endocrinology
  • Oncology

Background:

  • Prolactinomas are pituitary tumors that secrete prolactin.
  • Dopamine-agonists (DAs) are the primary medical treatment.
  • Concerns exist regarding long-term DA side effects and efficacy.

Purpose of the Study:

  • To evaluate the contemporary role of transsphenoidal surgery (TSS) for prolactinoma treatment.
  • To compare TSS with dopamine-agonist (DA) therapy.

Main Methods:

  • Review of contemporary literature and clinical experience.
  • Analysis of surgical outcomes, including normoprolactinemia rates and pituitary function preservation.
  • Consideration of cost-utility and patient-specific factors.

Main Results:

  • TSS achieves normoprolactinemia in 71-100% of microprolactinomas and similar results for macroprolactinomas.
  • Pituitary function is preserved with experienced TSS.
  • TSS is cost-effective and avoids risks associated with long-term DA use, such as cardiac valve disease.

Conclusions:

  • TSS is an effective alternative to DAs for prolactinomas, with expanded indications.
  • Patient desire for a potential cure makes TSS a significant option.
  • Both DA medication and TSS are effective modalities, usable complementarily.