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Does exercise-induced apelin affect sarcopenia? A systematic review and meta-analysis.

Jun Hyun Bae¹, Seong Eun Kwak¹, Ji Hyun Lee¹

¹Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, 71-1 410, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.

Hormones (Athens, Greece)

|December 20, 2019

Summary

Exercise increases serum apelin levels, which may benefit metabolic diseases. This systematic review analyzed exercise interventions to understand apelin

Keywords:

Apelin Exercise Meta-analysis Sarcopenia Systemic review

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Area of Science:

Exercise physiology
Endocrinology
Gerontology

Background:

Apelin is a novel protein identified in 1998, known for its role in muscular function and pathological processes.
Understanding apelin's response to exercise is crucial for developing targeted interventions, especially for older adults.

Purpose of the Study:

To systematically review and meta-analyze the effect of exercise on serum apelin levels.
To provide data for developing exercise interventions for older adults.

Main Methods:

Searched PubMed, Ovid MEDLINE, and EMBASE databases up to May 31, 2019.
Conducted a meta-analysis of nine studies using Hedge's statistic effect size (Zr) for weight mean difference (WMD).
Employed fixed-effect or random-effects models based on heterogeneity tests (I² statistic).

Main Results:

Exercise was found to increase serum apelin levels.
This increase in apelin is potentially beneficial for metabolic diseases like diabetes.
Subgroup analysis indicated significant effects in the 50-60-year-old age group, irrespective of BMI.

Conclusions:

Further research is needed to detail the effects of resistance and aerobic exercise on apelin levels.
Clarifying exercise parameters (frequency, type, intensity, time) is essential.
Investigating apelin's role in sarcopenia and cognitive disorders warrants further study.