Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin D2 in vertebrate evolution.

A W Hay1, G Watson

  • 1Nuffield Institute of Comparative Medicine, Zoological Society of London, U.K.

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
|January 1, 1977
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of <i>L. plantarum</i> on Caries Prevention and the Oral-Gut Microbiome In Vivo.

Journal of dental research·2025
Same author

'I can't relate to it': Exploring autistic and non-autistic adults' perceptions of the Australian Physical Activity and Sedentary Behaviour Guidelines.

Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals·2024
Same author

Increased Emergency Department Utilization and Costs for Medicare Cancer Patients with Malnutrition Diagnoses.

The journal of nutrition, health & aging·2022
Same author

Emerging themes in necrotising otitis externa: a scoping review of the literature from 2011 to 2020 and recommendations for future research.

The Journal of laryngology and otology·2021
Same author

Airway obstruction during general anaesthesia in a patient with a vagal nerve stimulator.

Anaesthesia reports·2020
Same author

Epidermal autophagy and beclin 1 regulator 1 and loricrin: a paradigm shift in the prognostication and stratification of the American Joint Committee on Cancer stage I melanomas.

The British journal of dermatology·2019
Same journal

RETINOID METABOLISM AND CONVERSION OF RETINOL TO DEHYDRORETINOL IN THE CRAYFISH (<i>PROCAMBARUS CLARKII</i>) RETINA.

Comparative biochemistry and physiology. B, Comparative biochemistry·2015
Same journal

Distribution of taurine and other free amino acids in the visual pathway of the crayfish procambarus clarkii.

Comparative biochemistry and physiology. B, Comparative biochemistry·2013
Same journal

Comparative study of free and membrane-bound acidic beta-D-glucosidase from the hepatopancreas of the shrimp Penaeus japonicus (Crustacea: decapoda).

Comparative biochemistry and physiology. B, Comparative biochemistry·2010
Same journal

Purification and characterization of an alpha-glucosidase from the hepatopancreas of the shrimp Penaeus japonicus (Crustacea: decapoda).

Comparative biochemistry and physiology. B, Comparative biochemistry·2010
Same journal

A neutral beta-galactosidase from the hepatopancreas of the shrimp Penaeus monodon (Crustacea: Decapoda): dimeric and sialyated.

Comparative biochemistry and physiology. B, Comparative biochemistry·2010
Same journal

Purification and properties of a beta-mannosidase from shrimp (Penaeus japonicus) hepatopancreas.

Comparative biochemistry and physiology. B, Comparative biochemistry·2010
See all related articles

Vitamin D transport proteins show varying affinities for different vitamin D forms across species. Placental mammals exhibit equal binding efficiency, while other vertebrates display preferential binding to 25-hydroxycholecalciferol.

Area of Science:

  • Comparative biochemistry
  • Endocrinology
  • Evolutionary biology

Background:

  • Vitamin D is crucial for calcium homeostasis and bone health.
  • Vitamin D exists in various forms, including ergocalciferol and cholecalciferol.
  • Specific plasma transport proteins bind and distribute vitamin D metabolites.

Purpose of the Study:

  • To investigate the binding affinities of vitamin D plasma transport proteins across diverse vertebrate species.
  • To compare the binding efficiency of 25-hydroxyergocalciferol and 25-hydroxycholecalciferol by these proteins.

Main Methods:

  • Plasma samples were collected from 63 vertebrate species.
  • Binding affinities of vitamin D transport proteins were assessed using specific assays.
  • Comparative analysis of protein binding efficiencies for the two vitamin D metabolites was performed.

Related Experiment Videos

Main Results:

  • Fish, reptile, bird, and monotreme plasma proteins bound 25-hydroxyergocalciferol less efficiently than 25-hydroxycholecalciferol.
  • Vitamin D transport proteins from 22 placental mammals bound both metabolites with equal efficiency.
  • Proteins from nine other mammals showed a 10-30% higher binding efficiency for 25-hydroxycholecalciferol compared to 25-hydroxyergocalciferol.

Conclusions:

  • Vertebrate vitamin D transport proteins exhibit species-specific binding preferences.
  • Placental mammals demonstrate a conserved, equal binding efficiency for key vitamin D metabolites.
  • Evolutionary divergence in vitamin D metabolism and transport is evident across the vertebrate”،