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Published on: September 22, 2020
A potential role for the CDH13/CDH15 gene in repeat revascularization after first percutaneous coronary intervention
Qian Xiang1, Zhiyan Liu1, Yun Lu2
1Department of Pharmacy, Peking University First Hospital, No. 6, Da Hong Luo Chang Street, Xicheng District, Beijing 100034, PR China.
Insights
Genetic markers in cell-extracellular matrix interactions may predict repeat coronary revascularization after percutaneous coronary intervention. This study identified CDH13 and CDH15 as potential biomarkers for restenosis risk.
Area of Science:
- Cardiovascular Genetics
- Interventional Cardiology
- Molecular Biology
Background:
- Percutaneous coronary intervention (PCI) is a common treatment for coronary artery disease.
- Restenosis and disease progression after PCI frequently lead to repeat revascularization procedures.
- Identifying genetic factors influencing these outcomes is crucial for personalized risk assessment.
Purpose of the Study:
- To identify genetic indicators that predict the risk of repeat revascularization following PCI.
- To explore the association between single nucleotide polymorphisms (SNPs) in relevant pathways and restenosis.
- To discover potential genetic biomarkers for predicting PCI outcomes.
Main Methods:
- A cohort of 143 patients undergoing PCI with available genetic data was analyzed.
- Single nucleotide polymorphisms (SNPs) were genotyped using the OmniZhongHua-8 platform.
- SNPs within genes involved in stenosis-related pathways, sourced from KEGG, BioCarta, and Gene Cards, were selected for analysis.
Main Results:
- The cell-extracellular matrix interactions pathway showed the most significant association with repeat revascularization.
- A specific SNP, rs72819363 in the CDH15 gene, was strongly linked to this outcome.
- Carriers of the A allele in CDH13 rs11859453 had a significantly reduced odds ratio for repeat revascularization at 18 and 30 months (0.25 and 0.33, respectively).
Conclusions:
- The cell-extracellular matrix interactions pathway plays a potential role in the development of coronary repeat revascularization.
- CDH13 and CDH15 gene variants may serve as predictive biomarkers for repeat revascularization after PCI.
- Further research is warranted to validate these genetic markers for clinical application.
Abstract:
Aim: Major drawbacks of percutaneous coronary intervention are the high occurrence of repeat revascularization due to restenosis and disease progression. The aim of this study was to find genetic indicators to predict the risk of repeat revascularization. Materials & methods: From April 2015 to June 2016, 143 patients with percutaneous coronary intervention with genetic test results were enrolled. SNPs were measured by OmniZhongHua-8, and the SNPs in pathways genes related to known stenosis-related processes from the KEGG, BioCarta and Gene Cards databases were selected for analysis. Results: Cell-extracellular matrix interactions were the pathways with the most significant SNP (CDH15 rs72819363) association with repeat revascularization. Compared with CDH13 rs11859453G carriers, the adjusted odds ratio for A carriers was 0.25 and 0.33 at 18 and 30 months. Conclusion: We demonstrated a potential role of the cell-extracellular matrix interactions pathway and the possible biomarker CDH13/CDH15 in the development of coronary repeat revascularization.
