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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
Published on: April 13, 2021
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Kidney Regeneration: Stem Cells as a New Trend
Amin Ahmadi1, Niloofar K Rad1,2, Vahid Ezzatizadeh3
1Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Current Stem Cell Research & Therapy
|December 20, 2019
Summary
Kidney disease affects millions globally. This review explores how stem cells from various sources can regenerate damaged kidney structures, offering potential therapeutic benefits for renal failure.
Area of Science:
- Nephrology
- Regenerative Medicine
- Stem Cell Biology
Background:
- Renal disease is a significant global health issue, impacting 10% of the population.
- Kidney failure results from irreversible nephron loss due to acute or chronic injury.
- Unlike humans, rodents exhibit postnatal nephrogenesis, and adult kidneys show partial repair capacity.
Purpose of the Study:
- To review the mechanisms of renal regeneration mediated by stem cells following kidney injury.
- To highlight the therapeutic potential of stem cells in treating renal failure.
Main Methods:
- Discussion of intrarenal and extra-renal cell sources for kidney maintenance and repair.
- Review of studies investigating stem cell contributions to kidney regeneration.
- Exploration of proposed mechanisms including cell dedifferentiation and resident stem cell activity.
Main Results:
- Stem cells from bone marrow, adipose tissue, skeletal muscle, umbilical cord, and amniotic fluid show therapeutic promise.
- Dedifferentiation of tubular epithelial cells and resident stem cells are key to kidney repair.
- Stem cell-based therapies offer potential for treating kidney injuries.
Conclusions:
- Stem cell therapy represents a promising avenue for renal regeneration and treating kidney disease.
- Understanding stem cell mechanisms is crucial for developing effective treatments for renal failure.
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