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Published on: May 27, 2021
[Clinical characteristics of children with Tourette's Syndrome]
Péter Nagy1, Emese Bognár, Luca Farkas
1Vadaskert Gyermekpszichiatriai Korhaz es Szakambulancia, Budapest, Hungary,
Insights
This study analyzed 137 children with Tourette Syndrome (TS), finding symptom severity correlated with age. Comorbidity rates were lower than international averages, particularly for ADHD, OCD, and ASD.
Area of Science:
- Neuroscience
- Child and Adolescent Psychiatry
Background:
- Tourette Syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics.
- Limited understanding exists regarding TS developmental trajectories, comorbidity, symptom severity, and genetic/environmental factors.
- This study focuses on characterizing patients from a specialized Tourette Syndrome Outpatient Clinic.
Purpose of the Study:
- To present the demographical characteristics of TS patients.
- To detail the comorbidity profile, tic types, and severity in a clinical sample.
- To compare findings with international Tourette Syndrome research.
Main Methods:
- A sample of 137 patients (ages 3-18) from a TS outpatient clinic was analyzed.
- Data collected included demographics, age at onset, family history, comorbidities, and perinatal events.
- The Yale Global Tic Severity Scale (YGTSS) was used to assess symptom severity.
Main Results:
- Average age at symptom onset was 5.9 years, with mean YGTSS score of 22.4.
- Common tics included simple head movements like blinking and head shaking.
- Comorbidities observed: Attention Deficit and Hyperactivity Disorder (ADHD) in 31%, Obsessive-Compulsive Disorder (OCD) in 10%, and Autism Spectrum Disorders (ASD) in 10%.
Conclusions:
- The demographic and clinical characteristics of the sample align with international TS reports.
- Notably, this sample exhibited lower comorbidity rates compared to those typically reported in the literature.
- Symptom severity showed a positive correlation with age, but not with other investigated factors.
Introduction:
Tourette Syndrome (TS) is a neurodevelopmental disorder presenting with motor and vocal tics. Although TS influences the everyday life of children, we only have fragmented knowledge on the topic of the developmental and comorbidity profile, symptom severity and genetical/environmental background. The aim of this article is to present the demographical characteristics, comorbidity profile and the tic symptom types and severity of patients from the Tourette Syndrome Outpatient Clinic of Vadaskert Child and Adolescent Psychiatry Hospital, Budapest.
Methods:
Our sample consists of all the patients (N=137), who visited the Tourette Syndrome Outpatient Clinic between February, 2012, and July, 2013. Patients were in the age range of 3 to 18 years. We recorded demographical and tic-specific data (age, symptom onset, TS in the family, comorbidity, adverse pre-/peri-/postnatal events) of the participants, and administered the Yale Global Tic Severity Scale (YGTSS).
Results:
The average age at symptom onset was 5.9 years. Average symptom severity (measured by the YGTSS) was 22.4 points. Comorbid Attention Deficit and Hyperactivity Disorder (ADHD) was reported in 31%, Obsessive-Compulsive Disorder (OCD) in 10%, and Autism Spectrum Disorders (ASD) in 10% of the sample. The most common tic types were simple head tics (blinking, shaking of head). Symptom severity correlated positively with age (p <0.05), but not with gender, age at symptom onset, positive family history for TS, or adverse pre-, peri-, and postnatal events.
Conclusion:
The characteristics of our sample does not show any major differences from international reports of similar samples. Comorbidity is an exception: our sample shows lower rates of comorbidities than usually reported.
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