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Related Experiment Video

Updated: Jan 1, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Circulating endocan and preeclampsia: a meta-analysis.

Xia Lan1, Zhaoming Liu1

  • 1Department of Obstetrics, Chong Qing Health Center for Women and Children, Chongqing 401147, China.

Bioscience Reports
|December 20, 2019
PubMed
Summary

Women with preeclampsia exhibit elevated circulating endocan levels compared to those with normal pregnancies. This finding suggests endocan as a potential biomarker for preeclampsia, regardless of disease onset timing.

Keywords:
endocanmeta-analysispreeclampsia

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Area of Science:

  • Biochemistry
  • Obstetrics
  • Pathophysiology

Background:

  • Endocan, a novel protein, is implicated in inflammation and endothelial dysfunction.
  • Previous studies on endocan's association with preeclampsia have yielded inconsistent results.
  • A clear understanding of circulating endocan levels in preeclampsia is needed.

Purpose of the Study:

  • To investigate the difference in circulating endocan levels between women with preeclampsia and those with normal pregnancies.
  • To consolidate existing evidence through a meta-analysis.

Main Methods:

  • Systematic search of PubMed and Embase databases for matched case-control studies.
  • Meta-analysis using random-effect or fixed-effect models based on heterogeneity.
  • Subgroup analysis to assess the impact of preeclampsia onset timing.

Main Results:

  • Eight studies with 451 preeclampsia cases and 442 controls were included.
  • Meta-analysis revealed significantly higher circulating endocan in preeclampsia patients (SMD = 0.37, P = 0.003).
  • No significant difference in endocan levels was observed between early-onset and late-onset preeclampsia subgroups.

Conclusions:

  • Women with preeclampsia demonstrate higher circulating endocan levels than normotensive pregnant women.
  • Circulating endocan may serve as a potential biomarker for preeclampsia.