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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

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Primary cutaneous plasmacytosis: a case report.

Adelina Costin¹, João Alves¹, Diogo Cerejeira¹

¹Department of Dermatology and Venereology, Garcia de Orta Hospital, Almada, Portugal.

Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica

|December 20, 2019

Summary

This summary is machine-generated.

Primary cutaneous plasmacytosis, a rare skin disorder involving plasma cell infiltration, is described in a Portuguese male. This case highlights the condition

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Area of Science:

Dermatology
Pathology
Immunology

Background:

Primary cutaneous plasmacytosis is a rare disorder.
It involves skin infiltration by polyclonal plasma cells.
The etiology is unknown, and it often presents with hypergammaglobulinemia and lymphadenopathy.

Observation:

The condition predominantly affects individuals of Japanese descent.
It is exceptionally rare in Caucasian populations.
A 36-year-old Portuguese male presented with disseminated reddish-brown plaques.

Findings:

The patient exhibited plaques on the trunk, neck, and upper limbs.
Laboratory tests revealed normal gammaglobulinemia levels.
The clinical presentation was consistent with primary cutaneous plasmacytosis.

Implications:

This case expands the known demographic profile of primary cutaneous plasmacytosis.
It suggests that the condition can occur in individuals of diverse ethnic backgrounds.
Further research is needed to understand the varied clinical presentations and underlying mechanisms.