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Related Experiment Video

Updated: Jan 1, 2026

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis

Published on: September 5, 2020

Spectral Imaging for Microbubble Characterization.

Richard J Browning¹, Miles Aron¹, Anna Booth^1,2

¹Department of Engineering Science, Institute of Biomedical Engineering , University of Oxford , Oxford OX3 7DQ , U.K.

Langmuir : the ACS Journal of Surfaces and Colloids

|December 20, 2019

Summary

This summary is machine-generated.

Spectral imaging reveals highly ordered lipid shells in microbubbles, primarily due to surface tension, not composition. This uniformity influences their acoustic response and stability for diagnostic and therapeutic uses.

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Area of Science:

Materials Science
Biophysics

Background:

Microbubbles with lipid shells are crucial for diagnostic and therapeutic applications.
Characterizing microbubble shell properties is challenging but vital for understanding their behavior.

Purpose of the Study:

To investigate spectral imaging for characterizing microbubble surface properties.
To compare lipid order, acoustic response, and stability across various microbubble formulations.

Main Methods:

Utilized spectral imaging with C-laurdan dye to assess lipid order in microbubble shells.
Correlated lipid order measurements with acoustic response and stability data.
Examined liposomes and ultrasound-generated debris for comparison.

Main Results:

Spectral imaging enabled rapid, high-throughput measurement of microbubble surface properties.
All tested microbubble formulations showed highly ordered lipid shells, irrespective of lipid composition.
Intact microbubbles exhibited higher and more uniform lipid order than liposomes or debris.

Conclusions:

High lipid order in microbubble shells is mainly driven by surface tension-induced compression, with minimal influence from composition.
Uniform lipid order explains consistent acoustic responses across different microbubble formulations.
Variability within microbubble populations highlights the need for improved manufacturing; lipid order differences are relevant for drug delivery applications.