Related Experiment Video
Updated: Jan 1, 2026
07:21
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
38.9K
Exogenous hormones and hereditary angioedema
Anne Gompel1, Olivier Fain2, Isabelle Boccon-Gibod3
1Université Paris Descartes, Gynécologie, 123 BD Du Port Royal, 75014 Paris, France; National Reference Centre for Angioedema (CREAK), France.
International Immunopharmacology
|December 20, 2019
Summary
Estrogen may worsen hereditary angioedema (HAE) attacks, while androgen offers potential long-term prophylactic treatment. This review explores hormone impacts on HAE in men and women.
Area of Science:
- Endocrinology
- Immunology
- Genetics
Background:
- Gonadal hormones, specifically estrogen and androgen, significantly influence bradykinin production.
- Bradykinin plays a crucial role in the pathophysiology of hereditary angioedema (HAE).
Purpose of the Study:
- To elucidate the impact of estrogen on hereditary angioedema pathophysiology.
- To review hormonal treatments and their effects on HAE course in both women and men.
Main Methods:
- Literature review focusing on hormonal influences in HAE.
- Analysis of studies concerning estrogen and androgen in HAE.
- Examination of hormone treatments including contraception, ART, menopause management, and cancer therapies.
Main Results:
- Estrogen may exacerbate HAE symptoms.
- Androgen demonstrates potential as a long-term prophylactic treatment for HAE.
- Hormone therapies like contraception, ART, and menopause management require careful consideration in HAE patients.
Conclusions:
- Hormonal modulation is critical in managing hereditary angioedema.
- Personalized treatment strategies considering gonadal hormone status are essential for effective HAE management in all patients.
Related Concept Videos
01:17Hormonal Regulation of Blood Pressure
5.7K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
5.7K
01:26Secondary Messengers in Hormone Action
4.5K
Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
4.5K
01:21Types of Hormones
6.3K
Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
6.3K
02:13Types of Hormones
82.7K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
82.7K
01:45Endocrine Signaling
67.5K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
67.5K
01:24Regulation of Angiogenesis and Blood Supply
3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K