Generalized AIC and chi-squared statistics for path models consistent with directed acyclic graphs
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Updated: Jan 1, 2026

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
Published on: July 1, 2020
1Département de biologie, Université de Sherbrooke, Sherbrooke, Quebec, J1K 2R1, Canada.
Abstract:
We explain how to obtain a generalized maximum-likelihood chi-square statistic, , and a full-model Akaike Information Criterion (AIC) statistic for piecewise structural equation modeling (SEM); that is, structural equations without latent variables whose causal topology can be represented as a directed acyclic graph (DAG). The full piecewise SEM is decomposed into submodels as a Markov network, each of which can have different distributional assumptions or functional links and that can be modeled by any method that produces maximum-likelihood parameter estimates. The generalized is a function of the difference in the maximum likelihoods of the model and its saturated equivalent and the full-model AIC is calculated by summing the AIC statistics of each of the submodels.
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