Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

437
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
437
Brain Imaging01:14

Brain Imaging

602
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
602
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

680
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
680
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

1.9K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.

Cellular & molecular biology letters·2024
Same author

Oocytes could rearrange immunoglobulin production to survive over adverse environmental stimuli.

Frontiers in immunology·2022
Same author

FBXW24 controls female meiotic prophase progression by regulating SYCP3 ubiquitination.

Clinical and translational medicine·2022
Same author

Changes in bile acid subtypes and long-term successful weight-loss in response to weight-loss diets: The POUNDS lost trial.

Liver international : official journal of the International Association for the Study of the Liver·2021
Same author

Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease.

Clinical journal of the American Society of Nephrology : CJASN·2021
Same author

Growth of 1D Nanorod Perovskite for Surface Passivation in FAPbI<sub>3</sub> Perovskite Solar Cells.

Small (Weinheim an der Bergstrasse, Germany)·2021

Related Experiment Video

Updated: Jan 1, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.5K

Prediabetes and structural brain abnormalities: Evidence from observational studies.

Jian-Bo Zhou1,2, Xing-Yao Tang3, Yi-Peng Han3

  • 1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Diabetes/Metabolism Research and Reviews
|December 20, 2019
PubMed
Summary

Prediabetes and elevated HbA1c levels are linked to brain abnormalities like infarcts and white matter changes. These conditions also correlate with reduced grey and white matter brain volumes, highlighting potential neurological risks.

Keywords:
glycosylated haemoglobinmeta-analysisprediabetesstructural brain abnormalities

More Related Videos

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.1K

Related Experiment Videos

Last Updated: Jan 1, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.5K
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.1K

Area of Science:

  • Neurology
  • Endocrinology
  • Public Health

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with structural brain abnormalities.
  • Evidence linking prediabetes to structural brain abnormalities requires systematic evaluation.

Purpose of the Study:

  • To systematically evaluate the association between prediabetes and structural brain abnormalities.
  • To synthesize existing evidence on the neurological impact of prediabetes and glycemic control.

Main Methods:

  • Systematic literature search across PubMed, Embase, Medline, and Web of Science.
  • Inclusion of twelve articles encompassing 104,468 individuals.
  • Stratified and regression analyses to assess associations between glycemic markers and brain structure.

Main Results:

  • Prediabetes and continuous HbA1c levels significantly increase the risk of infarcts and white matter hyperintensities.
  • Continuous HbA1c is associated with decreased brain volume (OR 0.92).
  • Prediabetes shows an inverse association with grey matter volume (WMD -9.65) and white matter volume (WMD -9.25).

Conclusions:

  • Both prediabetes and elevated HbA1c are linked to increased risks of cerebrovascular changes.
  • Glycemic control is a critical factor influencing brain structure, including grey and white matter volumes.
  • Further research is needed to understand the long-term effects of early diabetes onset on brain health.