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Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
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Parental adiposity differentially associates with newborn body composition

Eva C Diaz1,2,3, Mario A Cleves1,3, Marisha DiCarlo1,3

  • 1Arkansas Children's Nutrition Center, Little Rock, Arkansas.

Pediatric Obesity
|December 20, 2019
PubMed

Insights

Maternal adiposity is linked to increased newborn fat mass, while paternal adiposity shows a negative association in males. Parental fat mass also influences offspring growth factors at age two.

Area of Science:

  • Human health and development
  • Pediatrics
  • Endocrinology

Background:

  • Maternal obesity is a known risk factor for offspring obesity.
  • Limited research has explored the impact of parental metabolic health, physical activity, and paternal adiposity on offspring body composition.

Purpose of the Study:

  • To investigate the relationship between parental adiposity and newborn adiposity.
  • To explore associations between parental fat mass and offspring growth factors at age two.

Main Methods:

  • Utilized air displacement plethysmography to measure percent fat mass in mothers and newborns (2 weeks old).
  • Incorporated maternal factors like race, age, energy expenditure, physical activity, gestational weight gain, gestational age, delivery mode, infant sex, and feeding method into regression analyses.
  • Assessed the link between parental fat mass and offspring insulin-like growth factor 1 (IGF-1) at age two.

Main Results:

  • Maternal adiposity positively correlated with infant fat mass in both sexes.
  • Paternal adiposity showed a negative association with fat mass in male newborns.
  • Factors like breastfeeding, female infant sex, gestational age, and gestational weight gain were positively associated with newborn adiposity.

Conclusions:

  • Parental adiposity exhibits differential associations with newborn adiposity.
  • The underlying mechanisms driving these observed associations require further investigation.
Abstract

Keywords:
body compositionfoetal programminggrowth hormoneobesitypregnancy

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