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Lineariifolianoids M-O, three rare sesquiterpene lactone dimers inhibiting NO production from Inula lineariifolia
Ri-Xin Su1, Zhi-Li Wu2, Yuan-Yuan Wang2
1Guangdong Pharmaceutical University, 280 Waihuan East Road, Panyu District Guangdong, 510006, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.
Abstract:
Three rare squiterpene lactone dimers lineariifolianoids M-O (1-3) were isolated from Inula lineariifolia for the first time. Their structures and absolute configuration were established on the basis of by NMR and MS spectroscopic data and X-ray crystallography. Furthermore, those three compounds exhibited significant inhibitory activity against LPS-induced NO production in RAW 264.7 macrophages with IC50 values of 1.421, 1.087 and 1.243 μM, respectively.
