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Updated: Jan 1, 2026

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
Published on: September 26, 2015
Differential DNA Methylation Patterns in Patients with Epilepsy due to Malformations of Cortical Development: A Pilot
Kuntal Sen1, Rupali Gadkari2, Rajkumar Agarwal2
1Division of Neurogenetics and Developmental Pediatrics, Children's National Hospital, Washington, DC, USA.
Objective:
To study the DNA methylation profiles in brain tissue of patients with refractory epilepsy due to malformations of cortical development (MCDs).
Materials And Methods:
Clinical, neuroimaging, and pathology characteristics were defined for 13 patients who underwent resective surgery for epilepsy. Methylation analysis was performed using Illumina® 450k Methylation Microarray. Data analysis was completed, and pathway identification was done using the R/Bioconductor package.
Results:
Genes associated with Ephrin-Reelin pathway, potassium channels, and glutathione metabolism were differentially methylated in the MCD group when compared with patients who had no evidence of MCD.
Conclusions:
Our preliminary data reveal that epigenetic pathways may have a role in the pathobiogenesis of MCDs.
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