Related Experiment Video
Updated: Jan 1, 2026
07:09
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
2.2K
Heart failure with preserved ejection fraction: present status and future directions
1Department of Pharmacology, Chonnam National University Medical School, Hwasun, 58128, Republic of Korea.
Experimental & Molecular Medicine
|December 21, 2019
Summary
Heart failure with preserved ejection fraction (HFpEF) presents severe symptoms and mortality comparable to HFrEF. Current treatments effective for HFrEF show limited success in HFpEF, highlighting a critical unmet medical need.
Area of Science:
- Cardiology
- Translational Medicine
Background:
- Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized for its clinical significance.
- HFpEF is characterized by heart failure symptoms despite normal or near-normal echocardiographic findings.
- Key features include diastolic dysfunction, reduced ventricular compliance, and hypokinesia.
Purpose of the Study:
- To review the etiology and clinical features of HFpEF.
- To discuss the challenges in treating HFpEF compared to HF with reduced ejection fraction (HFrEF).
- To introduce the utility of animal models in studying HFpEF.
Main Methods:
- Review of existing literature on HFpEF.
- Analysis of clinical characteristics and patient outcomes.
- Examination of molecular mechanisms using small and medium-sized animal models.
Main Results:
- HFpEF shares severe mortality and survival rates with HFrEF.
- Standard HFrEF therapies (beta-blockers, RAAS inhibitors) lack comparable efficacy in HFpEF.
- Animal models are crucial for investigating HFpEF pathogenesis.
Conclusions:
- HFpEF poses a significant clinical challenge with limited therapeutic options.
- Understanding the molecular basis of HFpEF is essential for developing effective treatments.
- Animal models provide valuable insights into HFpEF mechanisms and potential therapeutic targets.
Related Concept Videos
01:17Pathophysiology of Heart Failure
2.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.6K
01:30Heart Failure IV: Classification and Diagnostic Evaluation
259
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
259
01:30Heart Failure V: Medical Management
176
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
176
01:29Heart Failure II: Pathophysiology
615
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
615
01:27Heart Failure I: Introduction
621
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
621
01:30Heart Failure VII: Nursing Interventions
370
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
370