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Updated: Jan 1, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Facile synthesis of supported Ru-Triphos catalysts for continuous flow application in selective nitrile reduction
Robert Konrath1,2, Frank J L Heutz1, Norbert Steinfeldt2
1School of Chemistry , University of St Andrews , North Haugh , St Andrews , Fife KY16 9ST , UK .
Abstract:
The selective catalytic hydrogenation of nitriles represents an important but challenging transformation for many homogeneous and heterogeneous catalysts. Herein, we report the efficient and modular solid-phase synthesis of immobilized Triphos-type ligands in very high yields, involving only minimal work-up procedures. The corresponding supported ruthenium-Triphos catalysts are tested in the hydrogenation of various nitriles. Under mild conditions and without the requirement of additives, the tunable supported catalyst library provides selective access to both primary amines and secondary imines. Moreover, the first application of a Triphos-type catalyst in a continuous flow process is presented demonstrating high catalyst life-time over at least 195 hours without significant activity loss.
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