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Updated: Jan 1, 2026
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
A primary cutaneous anaplastic large cell lymphoma mimicking labial herpes
Danielli Fernandes Pereira1, Bianca Scopel Costa2, Eduardo Filipe da Paz Scardua2
1Department of Dental Clinic, Espírito Santo Federal University, Avenida Maruípe 1468, Maruipe, Vitoria, CEP 29040-090, Brazil.
Introduction:
A primary cutaneous CD-30 positive T -cell lymphoproliferative disorders are rare and heterogeneous group of primary skin tumors, which include primary cutaneous anaplastic large cell lymphoma (PCALCL) and lymphomatoid papulois.
Case Report:
We report a rare an atypical case of PCALCL with an aggressive and refractory behavior that occurred in the lip vermilion, and that had been initially diagnosed as aggressive herpes. The lesion was recurrent and refractory to the CHOEP chemotherapy protocol followed by radiotherapy, but after hyper CVAD (acronym) + brentuximab with a considerable improvement. After 4 cycles of hyper CVAD plus brentuximab, the patient underwent 100% compatible sibling bone marrow transplantation, with success in the procedure.
Conclusion:
Primary cutaneous anaplastic large cell lymphoma is a rare disease of difficult diagnosis and may be confused with chronic infectious diseases, postponing treatment.
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