Haze facilitates sensitization to house dust mites in children

Allergy to house dust mites (HDMs) can cause allergic rhinitis, allergic asthma and allergic skin disorders, which is becoming an enormous worldwide health and economic burden. To explore the relationship between air pollution and HDMs sensitization in children, this study used immunoblotting to determine the concentration of HDM serum-specific IgE (sIgE) in children with allergic diseases in Hangzhou. HDM sIgE was used to reflect the sensitization of children with HDMs. Using the meteorological and atmospheric pollutant data for Hangzhou, a distributed lag nonlinear model was founded to evaluate the effect of atmospheric pollutants on HDMs sensitization. Particulate matter (PM) _2.5 and PM₁₀ were the main air pollutants in Hangzhou. The positive rate of HDM sIgE in children's serum increased with increasing PM_2.5 and PM₁₀ concentrations, and this effect was most obvious on the seventh and tenth days after increased PM_2.5 and PM₁₀ concentrations, respectively. In addition, there was a significant positive correlation between the concentration of HDM sIgE and the total serum IgE concentration. The rate of sensitization to HDMs rose dramatically in the first 3 years after birth. In addition, the period between June and November had the largest number of HDM sIgE-positive patients. Studies have shown that PM_2.5 and PM₁₀ are important factors in HDM sensitization, which presented obvious dose effects and lag effects. Children under the age of 3 years were the most susceptible to HDMs, and the period from June to November had a high risk of dust mite exposure. Avoiding exposure to particulate matter may have benefits in preventing HDM sensitization in children.