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Herpes simplex virus type 2 meningitis as a manifestation of Good's syndrome

Lorena Matta1,2, María Camila Ramírez-Velasco3, Andrés Felipe Zea-Vera4,5

  • 1Departamento de Medicina Interna, Facultad de Salud, Universidad del Valle, Cali, Colombia.

Journal of Neurovirology
|December 21, 2019
PubMed

Insights

Good's syndrome, a rare condition, links thymoma with immunodeficiency. This case highlights its varied symptoms, including neurological issues and chronic diarrhea, in an adult patient.

Area of Science:

  • Immunology
  • Neurology
  • Gastroenterology

Background:

  • Good's syndrome is a rare primary immunodeficiency characterized by thymoma and immune defects.
  • Clinical manifestations often include recurrent infections, hematological abnormalities, and chronic diarrhea.

Observation:

  • A 66-year-old man presented with headache, diplopia, and right sixth cranial nerve palsy.
  • He also reported chronic diarrhea, prolonged fever, and significant weight loss.
  • Diagnostic workup revealed Herpes simplex virus type 2 meningitis, eosinophilic colitis, and type A thymoma.

Findings:

  • The patient exhibited severe antibody deficiency (hypogammaglobulinemia).
  • The combination of thymoma and hypogammaglobulinemia confirmed the diagnosis of Good's syndrome.

Implications:

  • This case underscores the importance of considering Good's syndrome in adults presenting with a combination of neurological, gastrointestinal, and immunological symptoms.
  • Early diagnosis and management are crucial for improving patient outcomes in this rare condition.
Keywords:
Good’s syndromeHerpes simplex virus type (HSV) 2HypogammaglobulinemiaMollaret meningitisPrimary immunodeficiencyThymoma

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