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Updated: Jan 1, 2026
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Tumor microenvironment-activated nanosystems with selenophenol substituted BODIPYs as photosensitizers for
1Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, PR China.
Abstract:
NIR-light-absorbing photosensitizers with the capability of selective localization and activation in tumor regions are of great importance for practical photodynamic therapy (PDT). Here, selenophenol substituted BODIPYs were designed and synthesized as new photosensitizers for PDT. One of these obtained BODIPYs, IBSeOV, possesses an intense and low energy absorption with a high singlet oxygen quantum yield (ΦΔ = 60%). Considering manganese dioxide (MnO2) nanosheets as versatile nanocarriers in cancer theranostics, nanosystem IBSeOV/MnO2 was then fabricated to furnish tumor environment selective activation. Such designed nanoplatform allowed for GSH-controllable 1O2 production and exhibited low cytotoxicity in dark but good photocytotoxicity to cancer cells. The in vivo antitumor outcome suggested the high treatment efficiency of IBSeOV/MnO2 for tumor therapy.
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