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Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Updated: Jan 1, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Tracking the immune response with single-cell genomics.

Kathryn E Yost¹, Howard Y Chang², Ansuman T Satpathy³

¹Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.

|December 21, 2019

Summary

This summary is machine-generated.

Single-cell genomics reveals the complex diversity within immune cells, particularly T cells. This technology aids in understanding immune responses and developing effective vaccines.

Keywords:

Cancer immunology Single-cell genomics T cell receptor

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Last Updated: Jan 1, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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Published on: October 25, 2018

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Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations

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Published on: January 19, 2017

Area of Science:

Immunology
Genomics
Cell Biology

Background:

The immune system exhibits significant cellular diversity, with individual cells displaying varied differentiation and activation states.
Understanding this complexity is crucial for effective immune response orchestration against pathogens and cancer.
Single-cell resolution technologies have significantly advanced the study of immune cell heterogeneity.

Purpose of the Study:

To review recent advancements at the intersection of immunology and single-cell genomics.
To highlight the application of these technologies in analyzing immune cells.
To discuss the potential of single-cell genomics in vaccine research.

Main Methods:

Single-cell genomic profiling
Analysis of T cell receptor (TCR) loci rearrangements
Tracking clonal T cell responses

Main Results:

Single-cell genomics provides deep insights into immune cell heterogeneity.
Somatic rearrangements in TCR loci allow for tracking of T cell clonal expansion.
Technological advances facilitate detailed analysis of immune cell states.

Conclusions:

Single-cell genomics is a powerful tool for dissecting immune cell complexity.
Understanding T cell dynamics through TCR tracking is vital for immunology.
Future applications include elucidating mechanisms of vaccine-induced immunity.