Related Experiment Video
Updated: Jan 1, 2026

07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
18.1K
DIFFERENCES IN BONE AGE READINGS BETWEEN PEDIATRIC ENDOCRINOLOGISTS AND RADIOLOGISTS.
Summary
Pediatric endocrinologists (PEs) and radiologists differ in bone age (BA) interpretations, with PEs often reading their own X-rays. Discrepancies were noted in 68% of cases, particularly for precocious puberty (PP) referrals.
Area of Science:
- Pediatric Endocrinology
- Radiology
- Medical Imaging Analysis
Background:
- Pediatric endocrinologists (PEs) traditionally interpret bone age (BA) X-rays, believing radiologists lack accuracy.
- Systematic comparisons of BA interpretations between PEs and radiologists are lacking.
Purpose of the Study:
- To compare BA readings between PEs and radiologists.
- To identify clinical variables associated with discrepancies in BA interpretations.
Main Methods:
- Retrospective chart review of 103 children evaluated for short stature (SS) or precocious puberty (PP).
- Analysis of clinical variables including age, gender, ethnicity, Tanner stage, BMI, referral reason, and radiologist location.
- Bone age readings performed using the Greulich and Pyle method by both PEs and radiologists.
Main Results:
- A significant discrepancy (68%) was observed between PE and radiologist BA readings.
- Discrepancies ranged from -1.5 to 3.5 years, averaging 4 months.
- Patients referred for PP showed greater discrepancies (8.4 months) compared to SS referrals (0.8 months; P = .007).
Conclusions:
- Radiologists' BA interpretations differ from PEs in most cases.
- Potential bias related to referral reason may influence radiologist interpretations, especially in PP cases.
- Findings support the continued practice of independent BA interpretations by PEs.
Related Concept Videos
Changes in the Appendicular Skeleton with Age
3.3K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.3K
Pharmacokinetics in Pediatric Patients: Drug Metabolism
154
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
154
Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
202
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
202
Pharmacokinetics in Pediatric Patients: Drug Distribution
210
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
210
Pharmacokinetics in Pediatric Patients: Drug Excretion
173
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
173

