Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

207
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
207
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.6K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

306
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
306
Antibody Structure and Classes01:25

Antibody Structure and Classes

8.0K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
8.0K
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

140
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
140

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid efficacy of anifrolumab in refractory cutaneous dermatomyositis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Eosinophilic fasciitis induced by checkpoint inhibitors: a retrospective multicenter case-series, comparison with eosinophilic fasciitis unrelated to checkpoint inhibition and literature review.

Journal of the American Academy of Dermatology·2026
Same author

Gastrointestinal involvement in dermatomyositis: multicentric retrospective cohort study.

Rheumatology (Oxford, England)·2026
Same author

Longitudinal Trajectories of Antisynthetase Syndrome-associated Interstitial Lung Disease.

Archivos de bronconeumologia·2026
Same author

Electrodiagnostic Studies as a Diagnostic and Prognostic Tool in Acute Flaccid Myelitis.

Muscle & nerve·2026
Same author

Inflammation reprograms fibro-adipogenic progenitors to sustain immunopathogenic niches in myositis.

Cell death & disease·2026

Related Experiment Video

Updated: Jan 1, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

607

[Dermatomyositis: new antibody, new classification].

Loïs Bolko1, Cyril Gitiaux2, Yves Allenbach3

  • 1Service de Rhumatologie Maison Blanche, CHU de Reims, Reims, France.

Medecine Sciences : M/S
|December 21, 2019
PubMed
Summary

Dermatomyositis, a rare autoimmune disease, presents with skin issues and varies by specific autoantibodies. These antibodies, including anti-Mi2, anti-Tif1-γ, anti-NXP2, anti-MDA5, and anti-SAE, indicate distinct clinical features and prognoses.

More Related Videos

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.9K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.9K

Related Experiment Videos

Last Updated: Jan 1, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

607
Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

136.9K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.9K

Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Dermatomyositis is a rare chronic autoimmune disease.
  • Characterized by distinct cutaneous (skin) involvement.
  • Diagnosis occurs in childhood or adulthood.

Purpose of the Study:

  • To outline the clinical and histological presentations of dermatomyositis.
  • To correlate specific myositis autoantibodies with disease phenotypes.
  • To understand the diagnostic and prognostic implications of these autoantibodies.

Main Methods:

  • Review of clinical and serological data in dermatomyositis patients.
  • Classification based on five key myositis-specific autoantibodies: anti-Mi2, anti-Tif1-γ, anti-NXP2, anti-MDA5, and anti-SAE.
  • Analysis of associations between autoantibody profiles and clinical manifestations.

Main Results:

  • Anti-Mi2 antibodies are linked to the 'classical form' with skin and muscle involvement.
  • Anti-Tif1-γ and anti-NXP2 antibodies are associated with recurrent disease, prominent skin issues, and cancer in adults.
  • Anti-MDA5 antibodies indicate systemic involvement and interstitial lung disease; anti-SAE antibodies are found in adults with a classic form.

Conclusions:

  • Myositis-specific autoantibodies are crucial for classifying dermatomyositis.
  • Antibody profiles predict distinct clinical phenotypes, disease courses, and potential complications.
  • Understanding these associations aids in tailored diagnosis and management of dermatomyositis.