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IS THERE A DIFFERENCE BETWEEN RIGHT- VERSUS LEFT-SIDED COLON CANCERS? DOES SIDE MAKE ANY DIFFERENCE IN LONG-TERM
Leonardo Alfonso Bustamante-Lopez1, Sergio Carlos Nahas1, Caio Sergio R Nahas1
1Hospital das Clínicas, School of Medicine, Gastroenterology, University of São Paulo, São Paulo, SP, Brazil.
Right-sided colon cancer is associated with more advanced stage and poorer prognosis compared to left-sided colon cancer. Tumor stage, not location, significantly impacts survival in patients with colon cancer.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Oncology
Background:
- Colon cancer location (proximal vs. distal) may represent distinct disease entities due to differing embryologic origins.
- These differences could impact patient prognosis and treatment strategies for colorectal cancer.
Purpose of the Study:
- To compare characteristics of right-sided versus left-sided colon cancer.
- To identify tumor characteristics influencing survival in colon cancer patients.
Main Methods:
- Retrospective analysis of prospectively collected data.
- Evaluation of surgical treatment outcomes in colon cancer patients.
Main Results:
- Tumor location did not significantly influence overall survival in colon cancer patients (p=0.112).
- Advanced disease stage (III or IV) was the primary factor affecting survival.
- Right-sided colon cancer patients presented with more advanced staging, a 3.23 times greater risk of death, were older, and had more mucinous tumors.
Conclusions:
- Localized left-sided colon cancer demonstrates a better prognosis than right-sided colon cancer.
- Right-sided colon cancer is linked to more advanced stage, mucinous histology, and older patient age.
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