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Pseudomonas aeruginosa in the ICU: prevalence, resistance profile, and antimicrobial consumption

Ághata Cardoso da Silva Ribeiro1, Márcia Terezinha Lonardoni Crozatti1, Adilson Aderito da Silva2

  • 1Universidade Federal de São Paulo, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Diadema, SP, Brasil.

Revista Da Sociedade Brasileira De Medicina Tropical
|December 21, 2019
PubMed
Abstract

Insights

Pseudomonas aeruginosa infections are common in ICUs, with high rates of multidrug resistance. Increased antibiotic use correlates with rising resistance, highlighting the need for better monitoring to combat this threat.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Public Health

Background:

  • Pseudomonas aeruginosa is a significant pathogen in intensive care units (ICUs).
  • This bacterium frequently exhibits antimicrobial resistance, complicating treatment.

Purpose of the Study:

  • To analyze the prevalence and antimicrobial resistance patterns of Pseudomonas aeruginosa in ICUs.
  • To investigate the relationship between antimicrobial consumption and the emergence of resistant strains.

Main Methods:

  • Retrospective data collection from ICUs spanning 2010 to 2013.
  • Analysis of P. aeruginosa prevalence, multidrug resistance rates, and antimicrobial agent consumption.

Main Results:

  • P. aeruginosa prevalence was 14.5%, with 48.7% of isolates being multidrug-resistant.
  • Increasing resistance to carbapenems and polymyxin B was observed.
  • Significant correlations were found between resistance and consumption of amikacin, imipenem, meropenem, and polymyxin B.

Conclusions:

  • Enhanced surveillance of antimicrobial consumption and resistant microorganisms is crucial.
  • Interventions are needed to combat the growing threat of antimicrobial and multidrug resistance in ICUs.

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