Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Protein Maturation01:26

Bacterial Protein Maturation

392
Bacterial protein maturation is a tightly regulated process that ensures newly synthesized polypeptides achieve correct functional conformations. This maturation involves a series of modifications, folding events, and quality control steps, often assisted by specialized chaperone proteins.N-Terminal ModificationsThe maturation of bacterial polypeptides begins cotranslationally as the polypeptide exits the ribosome. The first amino acid, N-formylmethionine (fMet), is typically modified at the...
392
Diversity of Protists I01:15

Diversity of Protists I

777
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
777

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative effectiveness and safety of rituximab and caplacizumab for immuno-mediated Thrombotic Thrombocytopenic Purpura: an overview of systematic reviews.

Thrombosis research·2026
Same author

Multiple myeloma mortality in Latin America: Heterogeneous patterns and challenges in cross-country comparisons.

Cancer epidemiology·2026
Same author

Distribution of adult T-cell leukaemia/lymphoma subtypes and survival outcomes across geographical regions: An international retrospective cohort study.

British journal of haematology·2026
Same author

[Multiple Myeloma Without Monoclonal Component: Nonsecretory and Non-Producing. Case Report and Review].

Revista medica de Chile·2025
Same author

Prevalence and survival outcomes of adult T-cell leukemia/lymphoma in Latin America: A multicenter cohort study and recommendations to improve diagnosis and outcomes.

Cancer epidemiology·2025
Same author

Impact of the creation of a multidisciplinary amyloidosis study group in a public hospital of a developing Latin American country.

Hematology, transfusion and cell therapy·2025

Related Experiment Video

Updated: Jan 1, 2026

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

877

[Paraproteins. A review].

Camila Peña1

  • 1Sección Hematología, Hospital del Salvador, Santiago, Chile.

Revista Medica De Chile
|December 21, 2019
PubMed
Summary
This summary is machine-generated.

Monoclonal gammopathies (MG) involve mature B-cell neoplasms. Understanding lymphogenesis and diagnostic tests like protein electrophoresis (PEP), immunofixation (IFx), and serum free light chains (sFLC) is crucial for accurate MG diagnosis.

More Related Videos

Examining Proteasome Assembly with Recombinant Archaeal Proteasomes and Nondenaturing PAGE: The Case for a Combined Approach
09:57

Examining Proteasome Assembly with Recombinant Archaeal Proteasomes and Nondenaturing PAGE: The Case for a Combined Approach

Published on: December 17, 2016

6.9K
Directed Protein Packaging within Outer Membrane Vesicles from Escherichia coli: Design, Production and Purification
10:21

Directed Protein Packaging within Outer Membrane Vesicles from Escherichia coli: Design, Production and Purification

Published on: November 16, 2016

13.8K

Related Experiment Videos

Last Updated: Jan 1, 2026

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control
07:13

Author Spotlight: Developing Parmodulins to Target Protease-Activated Receptors for Inflammation Control

Published on: May 24, 2024

877
Examining Proteasome Assembly with Recombinant Archaeal Proteasomes and Nondenaturing PAGE: The Case for a Combined Approach
09:57

Examining Proteasome Assembly with Recombinant Archaeal Proteasomes and Nondenaturing PAGE: The Case for a Combined Approach

Published on: December 17, 2016

6.9K
Directed Protein Packaging within Outer Membrane Vesicles from Escherichia coli: Design, Production and Purification
10:21

Directed Protein Packaging within Outer Membrane Vesicles from Escherichia coli: Design, Production and Purification

Published on: November 16, 2016

13.8K

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Hematological neoplasms encompass tumors of varying cell maturation states.
  • Monoclonal gammopathies (MG) specifically arise from mature B-lymphocyte neoplasms.
  • Plasma cells, the final maturation stage of B-lymphocytes, are key in MG development.

Purpose of the Study:

  • To elucidate the relationship between lymphogenesis, plasma cell neoplasms, and monoclonal gammopathies.
  • To clarify the diagnostic utility of various laboratory tests for MG.
  • To emphasize the importance of appropriate diagnostic panels for MG detection.

Main Methods:

  • Review of lymphogenesis and B-cell maturation pathways.
  • Analysis of the role of plasma cells in monoclonal protein secretion.
  • Evaluation of diagnostic tests: protein electrophoresis (PEP), immunofixation (IFx), and serum free light chains (sFLC).

Main Results:

  • Monoclonal peaks, indicative of MG, are secreted by mature B-lymphocytes or plasma cells.
  • Hypogammaglobulinemia can also signify MG within the correct clinical context.
  • Current MG screening typically involves PEP, IFx, and sFLC; simpler panels are under investigation.

Conclusions:

  • Accurate diagnosis of monoclonal gammopathies requires understanding B-cell maturation and plasma cell function.
  • Protein electrophoresis alone is insufficient for comprehensive MG screening.
  • The combination of PEP, IFx, and sFLC provides a more robust diagnostic approach for MG.