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Spiny keratoderma: Report of three cases.

Thales Pereira de Azevedo¹, Celso Tavares Sodré¹, Christiana de Lima Santangelo¹

¹Sector of Dermatology and Post Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Journal of Cosmetic Dermatology

|December 21, 2019

Summary

Spiny keratoderma presents as rough, spiny papules on palms and soles. While often benign, it may rarely associate with systemic conditions like protein S deficiency or rectal cancer.

Keywords:

colorectal cancer keratoderma malignancy protein S deficiency spiny keratoderma

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Area of Science:

Dermatology
Genetics
Oncology

Background:

Spiny keratoderma is characterized by distinctive keratotic papules on the palms and soles.
These lesions typically cause cosmetic concerns and tactile roughness, without significant discomfort.

Observation:

Presents three cases of spiny keratoderma: one with protein S deficiency, another with rectal adenocarcinoma, and a familial case.
The condition has a long-standing presence, with cases reporting over 30-50 years of manifestation.
One patient experienced worsening of lesions after prolonged bed rest due to malignancy.

Findings:

Reviews epidemiologic data and differential diagnoses for spiny keratoderma.
Highlights potential associations with systemic diseases and malignancies in acquired cases.
Notes the rarity of spiny keratoderma in protein S deficiency and its infrequent link to rectal carcinoma.

Implications:

Emphasizes the importance of differentiating spiny keratoderma from other palmoplantar keratodermas, some of which are linked to malignancies.
Suggests further investigation into potential systemic associations of spiny keratoderma.
Underscores the need for a comprehensive diagnostic approach in patients presenting with spiny keratoderma.