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A Case Report from the Ancient Past.

William H Adams1

  • 1Retired, Hobart, NY, USA.

The American Journal of Case Reports
|December 21, 2019
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Summary
This summary is machine-generated.

Ancient Greek medicine described pituitary apoplexy and subsequent myxedema, a condition now linked to pituitary adenoma. This early observation predates modern understanding by 2400 years.

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Area of Science:

  • Medical History
  • Endocrinology
  • Classical Studies

Background:

  • Standard translations of Hippocratic texts may be inaccurate due to limited subject knowledge of translators.
  • Re-examination of ancient medical texts offers opportunities for novel interpretations and discoveries.

Observation:

  • A chapter from Hippocrates' Diseases II (5th century BCE) was newly translated and explicated.
  • The text describes patients experiencing pituitary apoplexy followed by myxedema, with a latency of up to 14 years.

Findings:

  • The Hippocratic text details a clinical presentation consistent with pituitary apoplexy and subsequent hormonal deficiency.
  • This observation suggests an early understanding of the pituitary gland's role in endocrine function.

Implications:

  • The association of myxedema with an earlier intracranial event described by Hippocrates predates modern causal links by 2400 years.
  • This finding highlights the advanced clinical observations present in ancient Greek medicine and informs our understanding of historical endocrinology.