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Related Experiment Video

Updated: Jan 1, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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Dosimetric evaluation of the Leksell GammaPlan™ Convolution dose calculation algorithm.

A Logothetis1, E Pantelis1, E Zoros1

  • 1Medical Physics Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Physics in Medicine and Biology
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The Leksell GammaPlan Convolution algorithm shows excellent dosimetric accuracy compared to Monte Carlo simulations for Gamma Knife stereotactic radiosurgery. Minor increases in beam on time were observed, particularly for complex cases.

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Area of Science:

  • Medical Physics
  • Radiotherapy Dosimetry
  • Radiation Oncology

Background:

  • Accurate dose calculation is critical for effective Gamma Knife stereotactic radiosurgery.
  • The Leksell GammaPlan Convolution algorithm is used for treatment planning.
  • Validation against Monte Carlo (MC) simulations provides a high standard for dosimetric accuracy.

Purpose of the Study:

  • To evaluate the dosimetric accuracy of the Leksell GammaPlan Convolution algorithm.
  • To compare Convolution algorithm calculations with Monte Carlo (MC) simulations.
  • To assess the algorithm's performance in homogeneous and inhomogeneous phantom geometries.

Main Methods:

  • Monte Carlo (MC) simulations were performed using validated Gamma Knife Perfexion source models.
  • Dosimetric results were compared using gamma index analysis (1%/1 mm criteria).
  • Simulations included various collimator sizes and irradiation field configurations (single, single shot, composite shot) in phantom geometries.

Main Results:

  • The Convolution algorithm demonstrated excellent agreement with MC calculations (gamma pass rate >98%).
  • Accurate dose calculations were observed in both homogeneous and heterogeneous phantom models.
  • Slightly increased beam on times (up to 7%) were noted compared to the TMR 10 algorithm, especially in complex clinical scenarios.

Conclusions:

  • The Leksell GammaPlan Convolution algorithm is highly accurate for Gamma Knife stereotactic radiosurgery dose calculations.
  • The algorithm's performance is reliable in various phantom geometries, supporting its clinical use.
  • Observed increases in beam on time are generally minor and do not significantly impact treatment planning.