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Updated: Jan 1, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Digital clubbing occurring in intrathoracic Hodgkin lymphoma: A case report
Rationale:
Digital clubbing is rarely associated with lymphoma. This study reports a case of intrathoracic Hodgkin lymphoma with digital clubbing and reviews the current literature regarding the clinical characteristics of this condition.
Patient Concern:
A 21-year-old woman presented with a 3-month history of cough and 1 month of fever, with apparent digital clubbing. A computed tomography (CT) scan of the lungs revealed a large pulmonary mass.
Diagnosis:
A CT-guided transthoracic needle biopsy was conducted. Pathology determined a diagnosis of Hodgkin lymphoma.
Interventions:
The patient underwent 6 courses of chemotherapy and intensification, followed by autografting.
Outcomes:
The patient recovered and a complete hematological remission was obtained. The patient is alive with no evidence of disease 60 months after diagnosis, with the digital clubbing of the fingers and toes completely resolved.
Conclusion:
Patients with digital clubbing and intrathoracic lesions need to be examined carefully to determine tumor malignancy.
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