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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Updated: Jan 1, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Genetically Engineered Mouse Models for Liver Cancer.

Kyungjoo Cho^1,2, Simon Weonsang Ro^1,3, Sang Hyun Seo¹

¹Yonsei Liver Center, Yonsei University College of Medicine, Seoul 03722, Korea.

|December 22, 2019

Summary

This summary is machine-generated.

Genetically engineered mouse models are advancing liver cancer research. New technologies like hydrodynamics-based transfection enable rapid creation of hepatocellular carcinoma models for drug discovery.

Keywords:

CRISPR/Cas9 genetically engineered mouse hepatocellular carcinoma hydrodynamics-based transfection sleeping beauty transposon

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Published on: August 29, 2016

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Last Updated: Jan 1, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

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Published on: September 12, 2019

Murine Bioluminescent Hepatic Tumour Model

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Published on: July 17, 2010

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Area of Science:

Oncology
Genetics
Translational Medicine

Background:

Liver cancer, primarily hepatocellular carcinoma (HCC), is a major global health concern, causing significant mortality.
Murine models are crucial for understanding HCC biopathology and developing new therapies.
Existing models include chemically-induced, xenograft, and genetically engineered mouse (GEM) models.

Purpose of the Study:

To review recent advancements in GEM models for HCC research.
To highlight novel technologies for creating HCC models.
To discuss the potential of these models for biomarker identification and therapeutic evaluation.

Main Methods:

Utilizing hydrodynamics-based transfection (HT) for rapid gene delivery in mice.
Employing the Sleeping Beauty transposon system and CRISPR/Cas9 genome editing.
Generating diverse HCC models with specific oncogene activation or tumor suppressor inactivation.

Main Results:

HT enables cost-effective and rapid generation of GEM models for HCC.
These models accurately reproduce human HCC characteristics.
A variety of models can be created to study different genetic alterations in hepatocarcinogenesis.

Conclusions:

GEM models, particularly those generated using HT, are powerful tools for studying liver cancer.
These models facilitate the investigation of genetic mechanisms in hepatocarcinogenesis.
Advancements in GEM models are expected to accelerate the development of targeted therapies and improve pre-clinical drug evaluation.