Related Experiment Video
Updated: Jan 1, 2026
07:23
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
8.9K
STAT3 Activation and Oncogenesis in Lymphoma
Fen Zhu1,2, Kevin Boyang Wang3, Lixin Rui1,2
1Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Cancers
|December 22, 2019
Summary
Constitutive activation of Signal transducer and activator of transcription 3 (STAT3) drives human lymphoma progression. Targeting the Janus kinase (JAK)/STAT3 pathway offers a promising therapeutic strategy for these cancers.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor in the Janus kinase (JAK)/STAT pathway.
- STAT3 regulates critical cellular processes including proliferation, survival, and inflammation.
- Aberrant STAT3 activation is implicated in numerous human cancers, including lymphoma.
Purpose of the Study:
- To review the oncogenic role of STAT3 in human lymphoma.
- To highlight therapeutic strategies targeting the JAK/STAT3 signaling pathway in lymphoma.
Main Methods:
- Literature review focusing on the role of STAT3 in lymphoma pathogenesis.
- Analysis of studies investigating JAK/STAT3 signaling in various lymphoma subtypes.
- Examination of therapeutic interventions targeting the JAK/STAT3 pathway.
Main Results:
- Constitutive STAT3 signaling acts as an oncogenic driver in both B-cell and T-cell lymphomas.
- Aberrant STAT3 activation contributes to tumor immune evasion by upregulating genes like PD-L1.
- Targeting JAK/STAT3 signaling demonstrates potential for lymphoma treatment.
Conclusions:
- STAT3 plays a critical oncogenic role in human lymphoma.
- Inhibition of the JAK/STAT3 pathway represents a viable therapeutic approach for lymphoma patients.
Related Concept Videos
02:23Abnormal Proliferation
5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
03:03mTOR Signaling and Cancer Progression
4.5K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.5K
01:20The JAK-STAT Signaling Pathway
11.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
11.6K
01:31The Intrinsic Apoptotic Pathway
8.1K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
8.1K
01:24B Cell Activation and Differentiation
15.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.7K
01:22T Cell Activation and Clonal Selection
14.5K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
14.5K