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STAT3 Activation and Oncogenesis in Lymphoma

Fen Zhu1,2, Kevin Boyang Wang3, Lixin Rui1,2

  • 1Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

Cancers
|December 22, 2019
PubMed

Insights

Constitutive activation of Signal transducer and activator of transcription 3 (STAT3) drives human lymphoma progression. Targeting the Janus kinase (JAK)/STAT3 pathway offers a promising therapeutic strategy for these cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor in the Janus kinase (JAK)/STAT pathway.
  • STAT3 regulates critical cellular processes including proliferation, survival, and inflammation.
  • Aberrant STAT3 activation is implicated in numerous human cancers, including lymphoma.

Purpose of the Study:

  • To review the oncogenic role of STAT3 in human lymphoma.
  • To highlight therapeutic strategies targeting the JAK/STAT3 signaling pathway in lymphoma.

Main Methods:

  • Literature review focusing on the role of STAT3 in lymphoma pathogenesis.
  • Analysis of studies investigating JAK/STAT3 signaling in various lymphoma subtypes.
  • Examination of therapeutic interventions targeting the JAK/STAT3 pathway.

Main Results:

  • Constitutive STAT3 signaling acts as an oncogenic driver in both B-cell and T-cell lymphomas.
  • Aberrant STAT3 activation contributes to tumor immune evasion by upregulating genes like PD-L1.
  • Targeting JAK/STAT3 signaling demonstrates potential for lymphoma treatment.

Conclusions:

  • STAT3 plays a critical oncogenic role in human lymphoma.
  • Inhibition of the JAK/STAT3 pathway represents a viable therapeutic approach for lymphoma patients.
Keywords:
STAT3gene transcription and targeted therapylymphomaoncogene

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