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Updated: Jan 1, 2026
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A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
Published on: September 16, 2022
3.5K
Candida spp./Bacteria Mixed Biofilms.
Maria Elisa Rodrigues1, Fernanda Gomes1, Célia F Rodrigues2
1CEB, Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, 4710-057 Braga, Portugal.
Journal of Fungi (Basel, Switzerland)
|December 22, 2019
Summary
Biofilms formed by fungi and bacteria present significant challenges due to their drug resistance. This review covers the epidemiology, eradication difficulties, and treatments for these complex microbial communities.
Area of Science:
- Microbiology
- Infectious Diseases
- Medical Mycology
Background:
- Microorganisms like bacteria and fungi commonly form biofilms.
- Biofilms colonize surfaces, leading to drug-resistant infections compared to planktonic forms.
- Polymicrobial biofilms, especially those involving fungi and bacteria, pose critical therapeutic challenges.
Purpose of the Study:
- To review the epidemiology of Candida spp.-bacteria biofilms.
- To discuss the challenges associated with eradicating these biofilms.
- To highlight the most relevant treatment strategies for fungal-bacterial biofilms.
Main Methods:
- Literature review focusing on polymicrobial biofilms.
- Epidemiological data analysis of Candida spp. and bacterial co-infections.
- Synthesis of current knowledge on biofilm eradication and treatment.
Main Results:
- Candida spp.-bacteria biofilms are prevalent in clinical settings.
- These biofilms exhibit enhanced resistance to antimicrobial agents.
- Significant challenges exist in their diagnosis and treatment.
Conclusions:
- Candida spp.-bacteria biofilms represent a growing clinical concern.
- Effective eradication requires understanding their unique epidemiology and resistance mechanisms.
- Further research into novel therapeutic approaches is crucial.
