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Anemia in centenarians: prevalence and association with kidney function
Wangping Jia1,2, Shengshu Wang1, Miao Liu1
1Institute of geriatrics, the 2nd Medical Center, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Chinese PLA General Hospital, Beijing, People's Republic of China.
Hematology (Amsterdam, Netherlands)
|December 22, 2019
Summary
Anemia is highly prevalent in Chinese centenarians, especially men. Declining kidney function is a key factor associated with anemia in this population, particularly for Han Chinese and those with diabetes.
Area of Science:
- Gerontology
- Nephrology
- Hematology
Background:
- Anemia is a common condition associated with increased morbidity and mortality, particularly in aging populations.
- Limited data exists on anemia prevalence and risk factors in centenarians.
Purpose of the Study:
- To determine the prevalence of anemia in Chinese centenarians.
- To investigate the relationship between anemia and declining kidney function in this demographic.
Main Methods:
- A population-based cross-sectional study involving 1002 Chinese centenarians (2014-2016).
- Anemia defined by hemoglobin levels: <130 g/L for men, <120 g/L for women.
- Estimated glomerular filtration rate (eGFR) used to assess kidney function.
Main Results:
- Anemia prevalence was 68.5% (men: 76.1%, women: 66.8%); severe anemia (>100 g/L) was 19.6%.
- A nonlinear relationship was observed between anemia risk and eGFR (P=0.021).
- Ethnicity and diabetes mellitus influenced the association between reduced eGFR (<60 mL/min/1.73 m²) and anemia.
Conclusions:
- Anemia is highly prevalent in Chinese centenarians, with higher rates in men.
- Reduced kidney function is an independent predictor of anemia in centenarians.
- Consideration of decreased kidney function is crucial for managing anemia in the very elderly.
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