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Nitric oxide and tumor metabolic reprogramming

Laura M López-Sánchez1, Enrique Aranda2, Antonio Rodríguez-Ariza2

  • 1Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Av. Menéndez Pidal s/n, E14004 Córdoba, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Av. Monforte de Lemos, 3-5, E 28029 Madrid, Spain.

Biochemical Pharmacology
|December 22, 2019
PubMed

Insights

Nitric oxide (NO) reprograms cancer cell metabolism, influencing nutrient use and mitochondrial function. This metabolic rewiring aids tumor growth, invasion, and immune evasion, with protein S-nitrosylation as a key mechanism.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Metabolism

Background:

  • Nitric oxide (NO) plays a complex role in tumor progression.
  • Mechanisms linking NO to tumorigenesis, particularly metabolic reprogramming, require further elucidation.

Purpose of the Study:

  • To review recent advances in understanding NO's role in cancer metabolic reprogramming.
  • To highlight how NO influences cancer cell metabolism and the tumor microenvironment.

Main Methods:

  • Literature review of recent research on NO and cancer metabolism.
  • Discussion of NO's impact on glucose/glutamine utilization, mitochondrial function, and S-nitrosylation.

Main Results:

  • NO influences glucose and glutamine metabolism in tumor cells.
  • NO regulates mitochondrial function and dynamics, supporting cancer proliferation.
  • NO-mediated metabolic changes affect the tumor microenvironment, promoting invasion and immune escape.

Conclusions:

  • Metabolic reprogramming is a critical aspect of NO's multifaceted role in cancer.
  • Protein S-nitrosylation is a central mechanism for NO-induced metabolic alterations.
  • Further research into S-nitrosylation/denitrosylation is crucial for understanding NO's impact on cancer metabolism and the tumor microenvironment.
Keywords:
CancerGlycolysisMetabolismMitochondriaNitric oxideS-nitrosylation

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