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Porous gold layer coated silver nanoplates with efficient antimicrobial activity
Jianfeng Zhu1, Shiyi Liu1, Taixing Zhang1
1College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China; Shenzhen Research Institute of Nanjing University, Shenzhen, 518057, China.
Colloids and Surfaces. B, Biointerfaces
|December 22, 2019
Summary
Porous silver-gold (Ag@Au) nanoplates offer a solution to silver nanoparticle toxicity. Laser-irradiated Ag@Au nanoplates demonstrate potent antibacterial effects and accelerate wound healing with reduced cytotoxicity.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Silver nanoparticles (AgNPs) show antibacterial properties but suffer from acute silver ion (Ag+) cytotoxicity.
- This toxicity limits the practical application of AgNPs in medicine, particularly for wound healing.
Purpose of the Study:
- To fabricate porous Ag@Au nanoplates that balance Ag+ release and nanoparticle toxicity.
- To investigate the antimicrobial activity and wound healing efficacy of these nanoplates, especially after laser irradiation.
Main Methods:
- Fabrication of porous Ag@Au nanoplates via stepwise seed-mediated growth and oxidation.
- Evaluation of antimicrobial activity against Staphylococcus aureus (S. aureus) strains.
- Assessment of in vitro cytotoxicity.
- Testing the wound healing effect on S. aureus-infected wounds.
Main Results:
- Porous Ag@Au nanoplates effectively balanced Ag+ release and toxicity.
- Laser irradiation enhanced the antimicrobial activity and wound healing rate.
- Irradiated porous Ag@Au nanoplates exhibited similar efficacy against S. aureus compared to Ag nanoplates but with lower cytotoxicity.
- The nanoplates demonstrated the best therapeutic effect in treating infected wounds.
Conclusions:
- Porous Ag@Au nanoplates are promising antibacterial agents for wound healing.
- Laser irradiation is a viable method to enhance their therapeutic potential.
- These nanoplates offer a safer and more effective alternative to traditional AgNPs for biomedical applications.
