Related Experiment Video
Updated: Jan 1, 2026

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios
Published on: August 4, 2023
To stage, or not to stage
Kelly Del Tredici1, Heiko Braak1
1Clinical Neuroanatomy Section/Department of Neurology, University of Ulm, 89081 Ulm, Germany.
Abstract:
Staging of neurodegenerative diseases is based chiefly on the topographical or anatomical extent of aggregated proteinaceous inclusions, and the density or severity of the lesions in a given region is usually assessed semiquantitatively. Associated phenomena, such as cell loss and synapse loss, are evaluated but not staged. This article reviews the development of neuropathological staging of the sporadic Alzheimer's and sporadic Parkinson's diseases. It considers challenges for staging systems, and it poses the question whether neuropathological staging as practiced up to now is still relevant.
Related Concept Videos
Self-Presentation: Self-Monitoring and Self-Handicapping
Impression Management Techniques I: Managing Appearances
Stages of Infection
Stages of General Anesthesia
Kubler Ross's Stages of Dying
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...
Schemas

