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[Observations on neonatal infection]
L Hohenauer1, G Eidenberger, F Eitelberger
1Neugeborenen-und Säuglingsabteilung des Landes-Kinderkrankenhauses Linz.
Padiatrie Und Padologie
|January 1, 1988
Summary
Neonatal sepsis, a serious infection in newborns, affected 60 infants, with a 20% mortality rate. Penicillin-resistant Staphylococcus epidermidis was common, highlighting the need for alternative treatments and preventative measures like hospital hygiene.
Area of Science:
- Neonatal intensive care
- Infectious diseases
- Pediatric medicine
Background:
- Sepsis neonatorum is a significant cause of mortality in newborns.
- Early and late onset sepsis present distinct etiological challenges.
- Antibiotic resistance is an increasing concern in neonatal infections.
Purpose of the Study:
- To analyze the incidence and outcomes of sepsis neonatorum in a neonatal intensive care unit.
- To identify common pathogens and their antibiotic susceptibility patterns.
- To evaluate current therapeutic strategies and suggest improvements.
Main Methods:
- Retrospective analysis of 829 neonatal intensive care patients from 1985-1986.
- Diagnosis of sepsis neonatorum based on clinical presentation and microbiological cultures.
- Assessment of pathogen identification and antibiotic sensitivity testing.
Main Results:
- 46 cases of early onset and 14 cases of late onset sepsis neonatorum were diagnosed.
- Overall mortality rate was 20%.
- Penicillin-resistant Staphylococcus epidermidis was identified in 40% of positive cultures, sensitive to Cefamandol, Netilmycine, and Amikacin.
Conclusions:
- Effective primary therapy for early onset sepsis must cover Streptococci and Listeria monocytogenes.
- Blood cultures are essential for accurate sepsis diagnosis.
- Hospital hygiene and immunotherapy are crucial components of neonatal sepsis management.