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[Observations on neonatal infection].

L Hohenauer1, G Eidenberger, F Eitelberger

  • 1Neugeborenen-und Säuglingsabteilung des Landes-Kinderkrankenhauses Linz.

Padiatrie Und Padologie
|January 1, 1988
PubMed
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Neonatal sepsis, a serious infection in newborns, affected 60 infants, with a 20% mortality rate. Penicillin-resistant Staphylococcus epidermidis was common, highlighting the need for alternative treatments and preventative measures like hospital hygiene.

Area of Science:

  • Neonatal intensive care
  • Infectious diseases
  • Pediatric medicine

Background:

  • Sepsis neonatorum is a significant cause of mortality in newborns.
  • Early and late onset sepsis present distinct etiological challenges.
  • Antibiotic resistance is an increasing concern in neonatal infections.

Purpose of the Study:

  • To analyze the incidence and outcomes of sepsis neonatorum in a neonatal intensive care unit.
  • To identify common pathogens and their antibiotic susceptibility patterns.
  • To evaluate current therapeutic strategies and suggest improvements.

Main Methods:

  • Retrospective analysis of 829 neonatal intensive care patients from 1985-1986.
  • Diagnosis of sepsis neonatorum based on clinical presentation and microbiological cultures.

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  • Assessment of pathogen identification and antibiotic sensitivity testing.

    • Main Results:

    • 46 cases of early onset and 14 cases of late onset sepsis neonatorum were diagnosed.
    • Overall mortality rate was 20%.
    • Penicillin-resistant Staphylococcus epidermidis was identified in 40% of positive cultures, sensitive to Cefamandol, Netilmycine, and Amikacin.

    Conclusions:

    • Effective primary therapy for early onset sepsis must cover Streptococci and Listeria monocytogenes.
    • Blood cultures are essential for accurate sepsis diagnosis.
    • Hospital hygiene and immunotherapy are crucial components of neonatal sepsis management.