Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

569
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
569
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

1.7K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
1.7K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Allergic Reactions02:06

Allergic Reactions

31.8K
Overview
31.8K
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

832
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
832
Hypersensitivities01:30

Hypersensitivities

6.6K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress ulcer prophylaxis practice in UK critical care units: A comparison of cross-sectional surveys between 2020 and 2024.

Journal of the Intensive Care Society·2025
Same author

Sedation modality in acute respiratory distress syndrome: does method of sedation affect length of stay, outcomes, or adverse events? A systematic review.

European journal of hospital pharmacy : science and practice·2024
Same author

Critical care pharmacy workforce: a 2020 re-evaluation of the UK deployment and characteristics.

Human resources for health·2023
Same author

Exploring the barriers and facilitators to non-medical prescribing experienced by pharmacists and physiotherapists, using focus groups.

BMC health services research·2022
Same author

Delayed gastric perforation following nasogastric tube insertion: the pitfalls of radiographic confirmation.

BMJ case reports·2021
Same author

Randomized trial of a brief peer support intervention for individuals with schizophrenia transitioning from hospital to community.

Schizophrenia research·2021

Related Experiment Video

Updated: Jan 1, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

15.5K

Sertraline-induced hypersensitivity pneumonitis.

Gursharan Virdee1, John Bleasdale2, Mohammed Ikramullah3

  • 1Pharmacy Department, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK gursharan.vryaparj@nhs.net.

BMJ Case Reports
|December 22, 2019
PubMed
Summary

Hypersensitivity pneumonitis (HP) is an allergic lung reaction to environmental triggers. This case report highlights a rare instance of HP caused by sertraline, emphasizing the need for broader awareness among healthcare providers.

Keywords:
Unwanted effects / adverse reactionsadult intensive careinterstitial lung diseasepsychiatry (drugs and medicines)respiratory medicine

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.5K

Related Experiment Videos

Last Updated: Jan 1, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

15.5K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.5K

Area of Science:

  • Pulmonology
  • Toxicology
  • Immunology

Background:

  • Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is a lung condition caused by hypersensitivity reactions to inhaled allergens.
  • It can manifest acutely, subacutely, or chronically, often linked to environmental exposures like mold or bird dust, and certain medications.
  • Severe cases of HP can lead to significant hypoxia and respiratory failure, necessitating prompt allergen identification and removal.

Observation:

  • This case report details a rare presentation of hypersensitivity pneumonitis (HP).
  • The condition was associated with the use of sertraline, a selective serotonin reuptake inhibitor (SSRI).
  • The report outlines the diagnostic process and successful treatment of HP in this context.

Findings:

  • Selective serotonin reuptake inhibitors (SSRIs) are infrequently implicated in causing hypersensitivity pneumonitis (HP).
  • This report provides evidence of sertraline as a potential etiological factor for HP.
  • The diagnosis and management of HP associated with sertraline were successfully achieved.

Implications:

  • Increased awareness of sertraline as a potential cause of hypersensitivity pneumonitis (HP) is crucial for clinicians.
  • This knowledge can aid multidisciplinary teams in diagnosing and managing HP, particularly when drug-induced causes are suspected.
  • Recognizing sertraline-induced HP may improve patient outcomes by facilitating timely allergen removal and appropriate treatment.