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Ageing, sex, and cardioprotection
Marisol Ruiz-Meana1,2, Kerstin Boengler3, David Garcia-Dorado1,2
1Hospital Universitari Vall d'Hebron, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autonoma de Barcelona, Barcelona, Spain.
British Journal of Pharmacology
|December 22, 2019
Summary
Age and sex significantly impact heart injury during ischaemia-reperfusion, affecting cardioprotective treatments. Strategies effective in young animals may fail in older individuals, highlighting the need for age- and sex-specific approaches in cardiovascular medicine.
Area of Science:
- Cardiovascular Medicine
- Translational Science
- Cardioprotection Research
Background:
- Translating cardioprotective interventions from experimental settings to clinical practice remains a significant challenge.
- Demographic and clinical factors, particularly age and sex, influence myocardial ischaemia-reperfusion injury and treatment efficacy.
- Existing cardioprotective strategies often show reduced effectiveness with advancing age.
Purpose of the Study:
- To review the mechanisms by which ageing and sex modulate myocardial ischaemia-reperfusion injury.
- To discuss the implications of these factors on the efficacy of cardioprotective interventions.
- To highlight the need for age- and sex-specific considerations in cardiovascular medicine.
Main Methods:
- Literature review of experimental and clinical studies.
- Analysis of the role of ageing and sex in ischaemia-reperfusion pathophysiology.
- Synthesis of findings related to cardioprotective strategies.
Main Results:
- Ageing and sex are critical modulators of myocardial ischaemia-reperfusion injury.
- Cardioprotective effects observed in young experimental models may not translate to aged populations.
- Understanding these sex- and age-related differences is crucial for effective treatment development.
Conclusions:
- Age and sex significantly influence the susceptibility to and outcomes of ischaemia-reperfusion injury.
- Current cardioprotective strategies require re-evaluation considering age and sex differences.
- Future research must focus on developing tailored interventions for diverse patient populations.