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Related Experiment Video

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Mouse Models Of Helicobacter Infection And Gastric Pathologies
07:43

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Low copper availability limits Helicobacter infection in mice.

Roberta Esposito1, Megi Vllahu1,2, Silvana Morello1

  • 1Department of Pharmacy, University of Salerno, Fisciano, Italy.

The FEBS Journal
|December 22, 2019
PubMed
Summary

This study shows that reducing copper levels in mice stomach hinders Helicobacter pylori colonization and gastric damage. However, administering copper chelators after infection worsens stomach conditions by impairing host defenses.

Keywords:
Helicobacter infectionTFF1copperinflammationtetrathiomolybdate

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Area of Science:

  • Microbiology
  • Nutritional Immunology
  • Pathogen-Host Interactions

Background:

  • Copper is essential but toxic at high concentrations, playing a role in host defense against pathogens.
  • Helicobacter pylori infection impacts host physiology, including micronutrient levels.

Purpose of the Study:

  • To investigate the impact of copper deprivation on Helicobacter pylori infection in a mouse model.
  • To understand the role of copper availability in the host-pathogen interaction during gastric infection.

Main Methods:

  • Utilized a copper chelator, tetrathiomolybdate, to induce copper deprivation in mice.
  • Infected mice with Helicobacter pylori and monitored bacterial colonization, gastric damage, and host gene expression.
  • Administered the copper chelator before and after infection to assess timing effects.

Main Results:

  • Helicobacter pylori infection significantly decreased gastric copper levels in mice.
  • Copper deprivation before infection reduced bacterial colonization and gastric lesions.
  • Post-infection administration of the copper chelator exacerbated gastric damage, suggesting impaired host immune response.
  • Trefoil factor 1 was upregulated in copper-deprived conditions, potentially conferring protection.

Conclusions:

  • Helicobacter pylori manipulates gastric copper levels, reducing host defense.
  • Copper availability is critical for controlling Helicobacter pylori infection outcome.
  • The timing of copper modulation influences the host's ability to combat infection.