Quantitative analysis for modified Schall's classification by stimulation test with dynamic scintigraphy in Sjögren's...

Area of Science:

• Nuclear Medicine
• Rheumatology
• Immunology

Background:

• Sjögren's syndrome (SS) is an autoimmune disease affecting salivary and lacrimal glands.
• Accurate classification and diagnosis are crucial for patient management.
• Schall's classification requires updating with advanced imaging techniques.

Purpose of the Study:

• To update Schall's classification for Sjögren's syndrome (SS) using quantitative stimulation test with dynamic salivary glands scintigraphy (qsDSGS).
• To standardize quantitative salivary gland scintigraphy for improved diagnostic accuracy.

Main Methods:

• Retrospective cohort study of 268 patients with suspected SS.
• Evaluation included histopathology, oral, ocular, serological tests, and qsDSGS.
• Quantitative analysis of qsDSGS determined diagnostic thresholds for functional parameters.

Main Results:

• Peak uptake level (PUL) and stimulation excretion fraction (sEF) identified as key imaging features.
• Modified Schall's classification categorized patients into four classes (1-4) based on disease severity.
• The modified classification showed good diagnostic performance for SS (88.4% specificity, 71.3% sensitivity).

Conclusions:

• The modified Schall's classification using qsDSGS standardizes quantitative salivary gland scintigraphy for SS.
• This updated classification is suitable for clinical research and daily practice in SS management.
• The new method enhances diagnostic convenience and suitability for SS patients.