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[Bronchial response to a provocation test in children allergic to Dermatophagoides pteronyssinus]
E Novembre1, G Veneruso, R Bernardini
1Clinica Pediatrica III, Università di Firenze, Italia.
Insights
Bronchial provocation tests effectively diagnose pediatric allergies. These tests confirm allergen involvement at the reaction site, aiding in allergy diagnosis for children.
Area of Science:
- Allergy and Immunology
- Pediatric Pulmonology
- Diagnostic Medicine
Background:
- Bronchial provocation tests are crucial for diagnosing allergic diseases.
- Confirming the role of specific allergens at the site of reaction is key in allergy diagnosis.
Purpose of the Study:
- To evaluate the utility of bronchial provocation tests in diagnosing pediatric allergy.
- To assess the response patterns to Dermatophagoides Pteronyssinus antigen challenge in children.
Main Methods:
- Twenty-seven children with confirmed allergies to Dermatophagoides Pteronyssinus (via skin tests and RAST) underwent bronchial provocation tests.
- Patients were challenged with Dermatophagoides Pteronyssinus antigen solutions, and responses were monitored.
Main Results:
- 77% of children showed positive responses to bronchial provocation.
- Observed response patterns included isolated early reactions, biphasic responses, and dual late reactions (including ultra-late reactions).
- Six patients (28.5%) exhibited negative reactions to the challenge.
Conclusions:
- Bronchial provocation tests, when performed as described, are a valuable diagnostic tool for pediatric allergy.
- The study demonstrates the feasibility and effectiveness of antigen-specific bronchial challenges in children.
Abstract:
Bronchial provocation tests with allergens are becoming recognized as one of the most important diagnostic parameters for the detection and confirmation of the role of the allergic component directly on the reaction site. Twenty-seven children with positive skin tests and RAST for Dermatophagoides Pteronyssinus were challenged with solutions of the same antigen. Twenty-one (77%) had positive responses expressed by different patterns: Six (28.5%) showed isolated early reaction, seven (33.3%) had biphasic responses. Six (28.5%) showed dual response with prolonged (1-2 hours) late reaction. One child had dual late reaction after 35 hours (ultra-late reaction). Six (28.5%) patients had negative reactions. The results suggest that bronchial provocation tests with antigens performed as outlined in this study can also be applied in the diagnosis of pediatric allergy.