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Risk factors of severe hand, foot and mouth disease in Shantou, China: a case-control study
Chunhua Liu1, Kaiyan Wang2, Niyang Lin3
1The First Affiliated Hospital of Shantou University Medical College, Shantou, China. chliu@stu.edu.cn.
Introduction:
In clinical perspectives, how to distinguish a small proportion of children at risk of developing neurological complications from a large number of children with mild symptoms still remains a challenge for primary care doctors.
Methodology:
From January 2012 to December 2015, 225 cases with severe hand, foot and mouth disease (HFMD) matched with 492 controls were enrolled in the age-matched, case-control study. Continuous variables were examined by univariate analysis using a chi-squared or Fisher's exact test, and categorical variables were reported by relative risks (odd's ratio). Multivariate logistic regression was used to analyze the independent risk factors for severe HFMD.
Results:
Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, enterovirus 71 (EV71) infection were independent risk factors for severe HFMD.
Conclusions:
Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, EV71 infection were independent risk factors for severe HFMD.
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